Hydroxyecdysone (Ecdysterone) Powder

Description

Basic Information

• Chemical Name: 20-Hydroxyecdysone
• Synonyms: Ecdysterone, 20E, Beta-Ecdysone
• Molecular Formula: C₂₇H₄₄O₇
• Molecular Weight: ~480.64 g/mol
• Class: Ecdysteroids (insect molting hormones)

🌿 Sources

• Plants (phytoecdysteroids), especially:
• Rhaponticum carthamoides (Leuzea)
• Spinach
• Asparagus
• •Quinoa
• Insects – regulates molting and reproduction
• Crustaceans – involved in exoskeleton shedding

🧠 Mechanism of Action (in humans)

• Bind to the estrogen receptor beta (ERβ), not androgen receptors.
• Stimulate protein synthesis via PI3K/Akt signaling pathway, much like anabolic steroids do—without the hormonal side effects.

🧪 Scientific Evidence

• A 2019 study by the University of Cologne (published in Archives of Toxicology) showed:
• Significant muscle mass and strength increases in subjects taking ecdysterone vs placebo.
• Results comparable to low-dose anabolic steroids.
• No hormonal suppression observed.

❗Caveats:

• •Most human studies are small in scale or poorly controlled.
• •Many claims are based on animal or cell studies.
• •Long-term safety in humans is not well studied.

⚖️ Legal Status

• WADA (World Anti-Doping Agency): Currently monitored under their Watch List, not banned (as of 2025).
• Legal for over-the-counter sale as a dietary supplement in most countries.
• Marketed under names like “Ecdysterone,” “Turkesterone” (a related compound), and “Leuzea extract.”

💊 Dosage & Use

• 200–500 mg/day (divided doses)
• Some users report benefits up to 1,000 mg/day, though more isn’t necessarily better.

⚠️ Side Effects & Safety

• No reported hormonal suppression
• No liver toxicity in normal doses
• No androgenic side effects (e.g., acne, hair loss)

❗Potential Risks:

• Limited long-term human data
• Quality control issues in supplements (adulteration, mislabeling)
• Overhyped marketing without robust clinical evidence

🧬 Related Compounds

• Compound Key Feature
• Turkesterone Similar structure; more expensive
• Ajugasterone C Found in Ajuga turkestanica
• Makisterone A Ecdysteroid in insects

🧴 Supplement Form & Stacking

• •Available in:
• •Capsules
• •Powders
• •Herbal extracts (Rhaponticum, Cyanotis, etc.)

Often stacked with:

• Creatine
• Protein
• BCAAs
• Other plant-based adaptogens

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