Slu-pp-332 powder

Description

What Is SLU-PP-332?

SLU-PP-332 powder is a synthetic small molecule that acts as an agonist of the estrogen-related receptors (ERRs) — specifically ERRα, ERRβ, and ERRγ. The chemical name is 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide, and its molecular formula is C₁₈H₁₄N₂O₂, molecular weight ~ 290.3 g/mol.

In simpler terms, this compound binds to and activates ERRs, which are nuclear receptors known to regulate metabolism, mitochondrial function, and energy homeostasis.

---

Biological Activity & Mechanism

ERR Activation & Cellular Effects

SLU-PP-332 demonstrates EC₅₀ values of:

• ~98 nM for ERRα

• ~230 nM for ERRβ

• ~430 nM for ERRγ

Because it is active across all three ERR isoforms (though with varying potency), it is considered a pan-ERR agonist. In cell culture and preclinical studies, it helps enhance mitochondrial respiration, increase energy expenditure, and improve cellular metabolic capacity. It also seems to increase oxidative muscle fiber types (e.g. type IIa) in skeletal muscle cells, which are more fatigue-resistant and metabolically active.

Animal / Preclinical Effects

Though human trials are not yet established, in mouse and rodent models SLU-PP-332 shows promise in:

• Improving glucose metabolism and insulin sensitivity.

• Reducing fat mass and promoting fat oxidation.

• Acting in a way somewhat analogous to “exercise mimetics”, i.e. triggering metabolic pathways that normally respond to physical activity.

These effects all stem from the idea that, by activating ERRs, SLU-PP-332 shifts cellular metabolism toward greater mitochondrial function, more efficient energy use, and enhanced oxidative capacity.

---

Pharmacology, Formulation & Stability

• Solubility & Form: SLU-PP-332 is stable as a solid and is often kept lyophilized (freeze-dried) at –20 °C for long-term storage. In solution form, stability decreases, so it’s recommended to use aliquots and avoid repeated freeze-thaw cycles.

• Solvents: It is soluble in DMSO and to some extent in ethanol, but insoluble (or poorly soluble) in water.

• Purity: Vendors list purities around ~98 % or above.

---

Potential & Challenges

Therapeutic Promise

Because mitochondrial dysfunction, metabolic syndrome, insulin resistance, obesity, and age-related decline in energy capacity are major health issues, compounds like SLU-PP-332 that target ERR-driven metabolism are of great interest. It holds potential as a therapeutic tool (or research tool) for metabolic diseases, muscle wasting, and possibly age-related disorders.

Obstacles & Unknowns

• Human safety and dosing: There is little to no published data in humans yet. Dosage regimens, pharmacokinetics, toxicity, and side effect profiles remain to be established.

• Selectivity and off-target effects: Because it targets multiple ERR isoforms, off-target signaling is possible at higher concentrations.

• Translation from mice to humans: Many compounds that work in rodents fail in human trials due to differences in metabolism, receptor expression, etc.

• Regulatory & ethical constraints: As of now, SLU-PP-332 is used in research settings — it is not approved for medical or over-the-counter use.

SLU-PP-332 powder is a promising research compound with potent pan-ERR agonism, capable of enhancing mitochondrial function, boosting energy metabolism, and mimicking some effects of exercise in animal studies. While preclinical data are encouraging, much remains unknown about how it behaves in humans. As always in science, the leap from “interesting compound” to “safe, effective therapy” is a long one. If you want, I can prepare a blog draft oriented more toward health / consumer audiences (with caveats) — would you like me to do that?